H‐2‐linked genetic control of antibody response to soluble calf skin collagen in mice
- 1 April 1975
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 5 (4), 288-291
- https://doi.org/10.1002/eji.1830050415
Abstract
An autosomal dominant immune response gene could be demonstrated in congenic resistant strains of mice which is linked to the H-2 locus and controls the antibody response to soluble calf collagen. High responsiveness was associated with the H-2 alleles, b and f, low responsiveness with the H-2 alleles, d, k, m and r. Studies with calf procollagen, which contains an additional carrier moiety, indicated that these genetic differences might be expressed at the level of T cells.Keywords
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