Degenerative arthritis in mice. Study of age and sex frequency in various strains with a genetic study of NZB/B1, NZY/B1, and hybrid mice.
Open Access
- 1 June 1977
- journal article
- research article
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 36 (3), 249-253
- https://doi.org/10.1136/ard.36.3.249
Abstract
Of a number of strains of mice studied for evidence of autoimmunity, NZY/B1 mice showed the highest frequency of degenerative arthritis of the knee, reaching a maximum of 68% at 18 months. 50% PN mice were affected at 24 months. Both breeds differed from previously described strains in not showing a sex difference. The NZB/B1 mice were rarely affected and hybrids to the NZY and the backcross to the NZB showed a recessive pattern of inheritance for knee arthritis and an additive pattern for carpal arthritis. Polygenic inheritance was postulated as at least three genes would be necessary to explain the findings. Joint disease was not related to red cell and nuclear antibodies, glomerulitis, or arteritis.This publication has 9 references indexed in Scilit:
- SPONTANEOUS ARTERITIS AND GLOMERULITIS IN MICE - COMPARISON OF LIGHT AND ELECTRON-MICROSCOPIC RENAL CHANGES IN PN-N, NZB-BL, 101-MAC, AND CBA-MAC MICE1975
- Polyarteritis Nodosa: The Natural History of a Spontaneously Occurring Model in Outbred MiceAustralasian Annals of Medicine, 1970
- Aging Changes and Osteoarthrosis in Castrate Mice Receiving ProgesteroneJournal of Gerontology, 1965
- Spontaneous Auto‐Immune Disease in NZB/BL MiceBritish Journal of Haematology, 1963
- The genetics of degenerative joint disease in miceArthritis & Rheumatism, 1962
- OSTEOARTHRITIS IN LABORATORY ANIMALS1959
- Idiopathic necrosis of bone in small laboratory animals.1958
- Age changes of bones and joints in various strains of miceJournal of Anatomy, 1941