Polymorphonuclear Leukocytes: Possible Mechanism of Accumulation in Psoriasis
- 16 December 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 198 (4322), 1162-1163
- https://doi.org/10.1126/science.929193
Abstract
Extracts of involved and uninvolved skin from nine patients with untreated psoriasis were studied for chemotactic activity. Psoriatic plaque contains increased amounts of a complement-dependent chemotactic factor that is inhibited by diisopropyl fluorophosphate. This factor may be human skin serine proteinase.This publication has 18 references indexed in Scilit:
- Cellular serine proteinase induces chemotaxis by complement activationNature, 1977
- Demonstration of C3 cleavage product in leukotactic substances of scale extract from pustular psoriasisBritish Journal of Dermatology, 1977
- Lysosomal hydrolases of the epidermis.British Journal of Dermatology, 1976
- Leukotactic properties of soluble substances inpsoriasis scaleBritish Journal of Dermatology, 1976
- Studies in ImmunodermatologyInternational Archives of Allergy and Immunology, 1975
- Studies in ImmunodermatologyInternational Archives of Allergy and Immunology, 1975
- BIOLOGICAL ACTIVITY OF COMPLEMENT IN VIVOThe Journal of Experimental Medicine, 1971
- Inflammation and Herpes Simplex Virus: Release of a Chemotaxis-Generating Factor from Infected CellsScience, 1970
- C3 LEUKOTACTIC FACTORS PRODUCED BY A TISSUE PROTEASEThe Journal of Experimental Medicine, 1969
- Autoradiographic Analysis of Turnover Times of Normal and Psoriatic Epidermis**From the Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Public Health Service, U.S. Department of Health, Education and Welfare.Journal of Investigative Dermatology, 1965