HLA association of idiopathic Peyronie's disease: An indication of autoimmune phenomena in etiopathogenesis?
- 1 July 1991
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 38 (1), 104-106
- https://doi.org/10.1111/j.1399-0039.1991.tb02021.x
Abstract
HLA typing for class I and class II antigens was done in 52 unrelated patients suffering from idiopathic Peyronie's disease. The controversially discussed association with the HLA-B7 cross-reacting group could not be confirmed. Marked deviations of antigen frequencies were observed for HLA-A1, B8, Cw7, DR3 and DQw2 compared to healthy local controls. After correction of p-values, Al (pc < 0.05) and DQw2 (pc < 0.01) remained significant. A possible association of Peyronie's disease with markers of the HLA-A1, B8, Cw7, DR3, DQw2 haplotype, as first described here, would suggest autoimmunological factors in this disorder of otherwise unknown etiopathogenesis.Keywords
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