Analgesic, Heart Rate, and Temperature Effects of Δ8-THC during Acute and Chronic Administration to Conscious Rats
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 15 (1), 65-72
- https://doi.org/10.1159/000136664
Abstract
Acute and chronic effects of △8-THC on tail-flick, heart rate, and rectal temperature responses in conscious, unrestrained male rats were studied. In the acute experiment unidirectional, dose-dependent analgesic, hypothermic, and negative chronotropic cardiac effects were observed within the dose range employed. Of the three variables, heart-rate decreases were most sensitive to the effects of THC, reaching significance at 2 mg/kg. Rapid development of tolerance occurred for all three measures, with complete tolerance developing within 13 days only to the heart-rate decreases. The results are discussed in the context of previous data.Keywords
This publication has 1 reference indexed in Scilit:
- Effect of internal and external cues on the heart rate of the rat.Canadian Journal of Psychology / Revue canadienne de psychologie, 1966