Identification of myxobacteria-derived HIV inhibitors by a high-throughput two-step infectivity assay
Open Access
- 24 September 2013
- journal article
- Published by Springer Nature in Microbial Cell Factories
- Vol. 12 (1), 85
- https://doi.org/10.1186/1475-2859-12-85
Abstract
Drug-resistance and therapy failure due to drug-drug interactions are the main challenges in current treatment against Human Immunodeficiency Virus (HIV) infection. As such, there is a continuous need for the development of new and more potent anti-HIV drugs. Here we established a high-throughput screen based on the highly permissive TZM-bl cell line to identify novel HIV inhibitors. The assay allows discriminating compounds acting on early and/or late steps of the HIV replication cycle.Keywords
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