Tumour Necrosis Factor B Gene Polymorphism in Relation to Complotype in Couples with Spontaneous Abortions and in Control Families
- 1 February 1992
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 35 (2), 131-135
- https://doi.org/10.1111/j.1365-3083.1992.tb02843.x
Abstract
NcoI restriction fragment length polymorphism (RFLP) of the tumour necrosis factor B (TNFB) gene gives two allelic fragments of 5.5 and 10.5 kb, corresponding to the TNFB*1 and TNFB*2 alleles, respectively. The frequencies of these alleles were analysed in 121 healthy Finns and 56 Finnish couples suffering from recurrent spontaneous abortions (RSA). In the healthy Finns the frequency of TNFB*1 was 37% and that of TNFB*2 63%, of which the frequency of TNFB*1 was significantly increased compared with the Danish population. No deviation was seen between the RSA couples and the Finnish controls. TNF genes are located in major histocompatibility complex class III region close to complement (BF, C4A and C4B) genes. Some complotypes associated most often with the TNFB*1 (S01, S30, S02) and some (S31, F320) with the TNFB*2 allele in the healthy Finns. The combination of the TNFB and the C4 'null' allele differed between the RSA couples and the Finnish controls.Keywords
This publication has 16 references indexed in Scilit:
- Thromboxane dominance and prostacyclin deficiency in habitual abortionThe Lancet, 1991
- A Tumour Necrosis Factor Beta Gene Polymorphism in Relation to Monokine Secretion and Insulin‐Dependent Diabetes MellitusScandinavian Journal of Immunology, 1991
- Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.The Journal of Experimental Medicine, 1991
- TNF‐alpha GENE POLYMORPHISMS: ASSOCIATION WITH TYPE I (INSULIN‐DEPENDENT) DIABETES MELLITUSInternational Journal of Immunogenetics, 1989
- Some disease-associated ancestral haplotypes carry a polymorphism of TNFHuman Immunology, 1989
- Nco I Restriction Fragment Length Polymorphism (RFLP) of the Tumor Necrosis Factor (TNFα) region in four autoimmune diseasesTissue Antigens, 1989
- Polymorphism in the tumor necrosis factor gene: Association with HLA-B and DR haplotypesHuman Immunology, 1988
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983
- An HLA Map of EuropeHuman Heredity, 1978
- GENETIC POLYMORPHISM IN HUMAN GLYCINE-RICH BETA-GLYCOPROTEINThe Journal of Experimental Medicine, 1972