Atrophy of Skeletal Muscle in Chick Embryos Treated with Botulinum Toxin
- 14 August 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 145 (3633), 719-721
- https://doi.org/10.1126/science.145.3633.719
Abstract
Botulinum toxin was given in large intravenous doses to 7- and 12- day chick embryos. Atrophy of skeletal muscle resulted without significant atrophy of other organs. The histological appearance of muscle was consistent with denervation. The results suggest that neural acetylcholine release may play a significant role in "trophic transmission" from nerve to muscle.Keywords
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