5‐Hydroxytryptamine metabolism in rat brain and liver homogenates
Open Access
- 1 September 1968
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 34 (1), 38-42
- https://doi.org/10.1111/j.1476-5381.1968.tb07948.x
Abstract
1 The metabolism of 5-hydroxyindoleacetaldehyde derived from 5-hydroxytryptamine incubated with tissue homogenates was studied as an indicator of aldehyde dehydrogenase and alcohol dehydrogenase activities. 2 In liver and brain from rats, there were indications of the presence of one or more aldehyde dehydrogenases which were stimulated by NAD+ to a greater extent than by NADP+. 3 In liver from rats, there were indications of the presence of one or more alcohol dehydrogenases, which were stimulated by NADH to a greater extent than by NADPH. 4 In brain from rats, there were indications of the presence of one or more alcohol dehydrogenases which were stimulated by NADPH to a greater extent than by NADH.Keywords
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