Accumulation of 24-Dehydrocholesterol in Rats Treated with 22,25-Diazacholestanol

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Abstract
Summary Oral administration of 22,25-diazacholestanol dihydrochloride to rats caused striking lowering of cholesterol and significant accumulation of desmosterol in the serum, liver and adrenals. The findings are similar to those in humans and suggest a triparanol-like mechanism of action.