Campylobacter Enteritis in Young Mice

Abstract

Young mice aged 4-6 wk and old mice aged 24-26 wk were inoculated with standard, single, oral doses of 2 strains of human pathogenic related campylobacters and in vitro small intestinal solute absorption and fluid transfer measured 7 days after inoculation. Young inoculated mice showed significantly lowered D-glucose and D-galactose absorption; in old inoculated mice, absorption of these solutes remained unaltered. In young inoculated mice, absorption of D-glucose was uniformly depressed in the distal 4/5 of the small intestine; absorption in the proximal 1/5 remained unaltered. Fluid transfer from the entire small intestine or segments of intestine remained unchanged 7 days after inoculation.