Studies on the β-Turn of Peptides. II. Syntheses and Conformational Properties of N-(2,4-Dinitrophenyl)tetrapeptide p-Nitroanilides Related to the β-Turn Part of Gramicidin S
- 1 May 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 56 (5), 1527-1531
- https://doi.org/10.1246/bcsj.56.1527
Abstract
N-(2,4-Dinitrophenyl)tetrapeptide p-nitroanilides related to the β-turn part of gramicidin S were synthesized and subjected to CD measurements. The β-turn preference of the tetrapeptide derivatives had correlation with the antibiotic activities of the gramicidin S analogs containing similar tetrapeptide sequences at their β-turn part. So, conformational preference of partial sequences of gramicidin S analogs seem to play a significant role for determining their biological activities.Keywords
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