Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry in Clinical Microbiology
Open Access
- 17 April 2013
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 57 (4), 564-572
- https://doi.org/10.1093/cid/cit247
Abstract
Despite widespread application of nucleic acid diagnostics, cultures remain integral in modern laboratories. Because cultures detect a large number of organism types, it is unlikely that they will disappear from clinical practice in the near future. Their downside is slow turn-around time, impacted by time to growth and identification of that growth. The latter is expedited using a new proteomic technology, matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS).Keywords
This publication has 69 references indexed in Scilit:
- Comparison of Vitek MS (MALDI-TOF) to standard routine identification methods: an advance but no panaceaPathology, 2012
- Performances of the Vitek MS Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Rapid Identification of Bacteria in Routine Clinical MicrobiologyJournal of Clinical Microbiology, 2012
- Routine Identification of Medical Fungi by the New Vitek MS Matrix-Assisted Laser Desorption Ionization–Time of Flight System with a New Time-Effective StrategyJournal of Clinical Microbiology, 2012
- Comparison of the Microflex LT and Vitek MS Systems for Routine Identification of Bacteria by Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass SpectrometryJournal of Clinical Microbiology, 2012
- Comparison of Bruker Biotyper Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometer to BD Phoenix Automated Microbiology System for Identification of Gram-Negative BacilliJournal of Clinical Microbiology, 2011
- Ongoing Revolution in Bacteriology: Routine Identification of Bacteria by Matrix‐Assisted Laser Desorption Ionization Time‐of‐Flight Mass SpectrometryClinical Infectious Diseases, 2009
- Evaluation of Matrix-Assisted Laser Desorption Ionization-Time-of-Flight Mass Spectrometry in Comparison to 16S rRNA Gene Sequencing for Species Identification of Nonfermenting BacteriaJournal of Clinical Microbiology, 2008
- Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltonsAnalytical Chemistry, 1988
- Protein and polymer analyses up to m/z 100 000 by laser ionization time‐of‐flight mass spectrometryRapid Communications in Mass Spectrometry, 1988
- Identification of bacteria using mass spectrometryAnalytical Chemistry, 1975