STUDIES ON THE FORMATION OF TRANSFER RIBONUCLEIC ACID-RIBOSOME COMPLEXES, XI. ANTIBIOTIC EFFECTS ON PHENYLALANYL-OLIGONUCLEOTIDE BINDING TO RIBOSOMES
- 1 October 1969
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 64 (2), 709-714
- https://doi.org/10.1073/pnas.64.2.709
Abstract
The effect of antibiotics on the binding of phenylalanyl-oligonucleotide to ribosomes has been examined. The results show that many classes of antibiotics can interfere with binding of the aminoacyl-oligonucleotide terminus of tRNA to ribosomes: chloramphenicol, sparsomycin, D-WIN-5094, vernamycin A, PA114A, streptogramin, amicetin, gougerotin, tylosin, and spiramycin III. The results are consistent with the hypothesis that these antibiotics inhibit protein synthesis by interfering with the binding of the aminoacyl-end of aminoacyl-tRNA to ribosomes.Keywords
This publication has 27 references indexed in Scilit:
- Studies on the formation of transfer ribonucleic acid-ribosome complexes X. phenylalanyl-oligonucleotide binding to ribosomes and the mechanism of chloramphenicol actionBiochemical and Biophysical Research Communications, 1969
- Action of Sparsomycin on Ribosome-catalysed Peptidyl TransferNature, 1969
- Studies on the formation of trensfer ribonucleic acid-ribosome complexes. V. On the function of a soluble transfer factor in protein synthesis.Proceedings of the National Academy of Sciences, 1968
- Studies on the reaction of N-acetyl-phenylalanyl-tRNA with puromycinArchives of Biochemistry and Biophysics, 1968
- Reaction of Ribosome-bound Peptidyl Transfer Ribonucleic Acid with Aminoacyl Transfer Ribonucleic Acid or PuromycinJournal of Biological Chemistry, 1967
- Inhibition by Sparsomycin and Other Antibiotics of the Puromycin-Induced Release of Polypeptide from Ribosomes*Biochemistry, 1967
- Effect of limiting concentrations of T1 ribonuclease on the release of aminoacyl-oligonucleotides from unfractionated yeast acceptor RNAJournal of Molecular Biology, 1967
- A RIBOSOME-CATALYZED REACTION BETWEEN N-FORMYLMETHIONYL-TRNA AND PUROMYCINProceedings of the National Academy of Sciences, 1966
- Differences in Chloramphenicol Sensitivity of Cell-free Amino Acid Polymerization SystemsJournal of Biological Chemistry, 1964
- The assimilation of amino-acids by bacteria. 15. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureusBiochemical Journal, 1953