A New Putative Neuroregulator of the Extrapyramidal System
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 17 (4), 210-214
- https://doi.org/10.1159/000136856
Abstract
A putative neurotransmitter, 2-phenylethylamine, which is most highly concentrated in the extrapyramidal system of human brain, is able to reverse reserpine-induced parkinsonism in animals and elicit stereotypy. This action is only partially antagonized after catecholamine depletion by pretreatment with α-methyl-paratyrosine, and fully blocked by pretreatment with haloperidol, a dopamine receptor blocker. Therefore, via direct and/or indirect actions, 2-phenyl-ethylamine may serve a neuroregulatory role in the extrapyramidal system.Keywords
This publication has 5 references indexed in Scilit:
- Chronic phenylethylamine stereotypy in rats: A new animal model for schizophrenia?Life Sciences, 1977
- Interaction of reserpine and ouabain on amine concentrating mechanisms in the adrenergic neuroneBiochemical Pharmacology, 1967
- The effect of β-phenylethylamine on central and peripheral monoamine-containing neuronsEuropean Journal of Pharmacology, 1967
- Pharmacology of the Mechanism of Certain Effects of Reserpine in the RatNature, 1967
- CLINICAL USE OF RESERPINE IN PSYCHIATRY: COMPARISON WITH CHLORPROMAZINEAnnals of the New York Academy of Sciences, 1955