Platelet‐activating factor mobilises intracellular calcium in vascular smooth muscle cells
- 3 March 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 197 (1-2), 13-16
- https://doi.org/10.1016/0014-5793(86)80288-5
Abstract
The effect of platelet-activating factor (PAF) on polyphosphoinositide metabolism and 45Ca2+ efflux was examined in a vascular smooth muscle cell line (A7r5). PAF stimulated a rapid but transient production of inositol trisphosphate and inositol bisphosphate which, in the presence of lithium, resulted in an accumulation of inositol monophosphate. In addition, PAF induced a rapid efflux of 45Ca2+ from preloaded cells, an effect which was concentration-dependent. These data suggest that PAF mobilises intracellular Ca2+ via the production of inositol trisphosphateKeywords
This publication has 33 references indexed in Scilit:
- Vasopressin induced production of inositol trisphosphate and calcium efflux in a smooth muscle cell lineBiochemical and Biophysical Research Communications, 1985
- Specific binding sites for platelet activating factor in human lung tissuesBiochemical and Biophysical Research Communications, 1985
- Bradykinin‐induced transient accumulation of inositol trisphosphate in neuron‐like cell line NG 108‐15 cellsFEBS Letters, 1985
- Specific binding of 1-[3H]-O-alkyl-2-acetyl-sn-glyceryl-3-phosphoryl choline (platelet-activating factor, PAF) by human polymorphonuclear neutrophilsInflammation Research, 1984
- Metabolism of inositol phosphates in parotid cells: Implications for the pathway of the phosphoinositide effect and for the possible messenger role of inositol trisphosphateLife Sciences, 1984
- Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphateNature, 1983
- Specific receptor sites for 1-0-alkyl-2-0-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on rabbit platelet and guinea pig smooth muscle membranesBiochemistry, 1983
- CV-3988 - A specific antagonist of platelet activating factor (PAF)Life Sciences, 1983
- Platelet activating factor (PAF‐acether) promotes an early degradation of phosphatidylinositol‐4,5‐biphosphate in rabbit plateletsFEBS Letters, 1983
- The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questionsPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1981