Immunochemical Evidence for the Development of an Acquired Hypogammaglobulinemic State

Abstract

TO account for the change in health of previously "normal" persons, characterized by susceptibility to infection and low serum immunoglobulins, the term "acquired" hypogammaglobulinemia has been proposed.^{1 2 3} The validity of this classification was substantiated by morphologic evidence recently offered by Charache et al.⁴ These workers documented the change of a normal lymphoid architecture, observed in an appendix removed in surgery, eight years before the appearance of the histologic lesion characteristic of the hypogammaglobulinemic state. To provide further data consistent with this concept of "acquired" hypogammaglobulinemia, we report a case in which, during the past four years, nearly complete loss of . . .