Metabolism, Storage, and Excretion of C14-Endosulfan in the Mouse1

Abstract

A portion of endosulfan, when fed to the laboratory mouse in single or multiple doses, is oxidized to the cyclic sulfate and stored in the body fat. No endosulfan per se, or any of the known metabolites are found in tissues or organs except the liver and kidney, both of which are involved in the metabolism and excretion. Purified endosulfan is not completely absorbed from the gastrointestinal tract, and is eliminated in the feces with 2 metabolites, the dial and sulfate. A metabolite appearing in the urine of mice fed either endosulfan, the sulfate, the diol, or the ether is believed to be the diol. The relative activities of organs and excreta of mice sacrificed 24 hours after ingesting C¹⁴-endosulfan were: feces>visceral Eat>urine>liver> small intestine plus contents>kidney>brain>respiratory CO₂>blood.