Our purpose in this paper is to present a case of a syndrome comparable to that described by Simmonds,1commonly known today as pituitary cachexia. Numerous cases have been reported in the European literature. Graham and Farquharson,2in 1931, reported the first cases in the American literature and stimulated an interest that has resulted in some important observations as to cause and therapy. That the condition is caused by a disturbance of the normal function of the anterior lobe of the hypophysis is hardly to be doubted, but the pathologic conditions producing it are still somewhat confusing. Silver3reviewed the literature in 1933 and found 41 cases in which the diagnosis had been confirmed post mortem. He found various pathologic processes of the pituitary gland—atrophy, tumors, cysts, replacement by fibrous tissue, tuberculous caseation, necrosis, inflammatory processes, syphilitic lesions, degeneration and hematoma, which resulted in destruction of the