Enhanced production of interleukin‐2 in patients with progressive systemic sclerosis. hyperactivity of cd4‐positive t cells?
Open Access
- 1 March 1988
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 31 (3), 401-407
- https://doi.org/10.1002/art.1780310312
Abstract
A significant enhancement of interleukin-2 production was observed in phytohemagglutinin-stimulated peripheral lymphocytes from patients with progressive systemic sclerosis (PSS). Their Leu-3a:Leu-2a ratio was also significantly higher than normal. Moreover, Leu-3a+ cells freshly purified from PSS patients' blood produced much more interleukin-2 than did cells from normal subjects. These results suggest that T cell hyperactivity, especially among Leu-3a+ T cells, occurs in patients with PSS.This publication has 34 references indexed in Scilit:
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