Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation
- 9 December 1991
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 294 (3), 158-162
- https://doi.org/10.1016/0014-5793(91)80658-p
Abstract
Free fatty acids, natural uncouplers of oxidative phosphorylation, are shown to differ from artificial ones in that they fail to increase conductance of phospholipid bilayers which are permeable for the protonated form of fatty acids but impermeable for their anionic form. Recent studies have revealed that uncoupling by fatty acids in mitochondria is mediated by the ATP/ADP antiporter and, in brown fat, by thermogenin which is structurally very similar to the antiporter. It is suggested that both the ATP/ADP antiporter and thermogenin facilitate translocation of the fatty anions through the mitochondrial membrane.Keywords
This publication has 33 references indexed in Scilit:
- Carboxyatractylate‐sensitive uncoupling in liver mitochondria from ground squirrels during hibernation and arousalFEBS Letters, 1990
- Inhibitors of the ATP/ADP antiporter suppress stimulation of mitochondrial respiration and H+ permeability by palmitate and anionic detergentsFEBS Letters, 1990
- Does the function of adenine nucleotide translocase in fatty acid uncoupling depend on the type of mitochondria?FEBS Letters, 1990
- Evidence for the existence of an inner membrane anion channel in mitochondriaBiochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1986
- Isolation of the uncoupling protein from brown adipose tissue mitochondriaFEBS Letters, 1980
- Brown adipose tissue mitochondriaBiochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1979
- A Source of Nonshivering Thermogenesis in Fur Seal Skeletal MuscleScience, 1979
- The bioenergetics of brown adipose tissue mitochondriaFEBS Letters, 1976
- Differential effects of mercurial reagents on mitochondrial thiol groups and mitochondrial permeabilityBiochemical and Biophysical Research Communications, 1968
- Effect of surface active agents on the latent ATPASE of mitochondiraBiochimica et Biophysica Acta, 1956