Immunologically active zones in bovine growth hormone

Abstract

Antigenic determinant areas were detected in bovine growth hormone fragments 6–124 and 125–149, the former being predominant. Reduction and carboxymethylation of disulfide bridge 53–164 destroys the immunological reactivity of the area which is little affected by reduction and carbamoylmethylation. All the activity found in fragment 6–124 seems to be concentrated in the sequence 87–124.