The purpose of this paper is to call attention to a chronic, recurrent, resistant vesicular eruption of the palms and fingers that is being seen with increasing frequency and that has certain characteristics that identify it as a definite entity. One and two-tenths per cent of cases seen in our private practice belong in this group. The predisposing factor in the appearance of this disease is chronic irritation of the affected parts, either through occupation or from overstimulating treatment of a simple dermatitis. The majority of cases observed appear in those exposed to hazardous occupations, such as machine operators, porters and bakers. Housewives, with their exposure to soap and hot water in the washing of dishes and clothes, to wide extremes of heat and cold in the kitchen and to house dust, are frequently victims of this disease. Its occurrence in the protected office worker is