Prevention of Peritoneal Adhesions by Silicone Solution
- 1 March 1967
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 94 (3), 384-387
- https://doi.org/10.1001/archsurg.1967.01330090078020
Abstract
THE DIFFERENT mechanisms of postoperative peritoneal adhesion formation have been elucidated. However, the prevention of these adhesions still presents a major problem. The methods that may be considered in prevention of postoperative adhesions may be classified into five different groups. 1. Peritonealization: covering all raw surfaces by peritoneum, omental, or amniotic membrane grafts.1,2 2. Mechanical separation of raw surfaces. This may be achieved in several ways. (a) Activation of early peristalsis by pharmacological (prostigmin) or mechanical methods (heat, diathermia, etc).3,4 (b) Introduction into peritoneal cavity of substances that will keep operative surfaces separated. This includes the introduction of isotonic solutions, amniotic fluid, macromolecular dextran, lubricants like polyvinylpyrolidone, and others1,5-10 (an unpublished data). 3. Anticoagulants applied locally.11 4. Fibrinolytic or proteolytic enzymes like streptokinase and streptodornase.11-14 5. Inhibition of connective tissue formation by corticoids applied locally or given systemically.14,15 Some of these methods have provedThis publication has 3 references indexed in Scilit:
- Cancer Induction by Polyurethan and Polysilicone PlasticsJNCI Journal of the National Cancer Institute, 1964
- Prevention of Experimental Peritoneal Adhesions by DextranArchives of Surgery, 1964
- THE EFFECT OF CORTISONE ON THE PREVENTION OF PERITONEAL ADHESIONS1953