Synthese DE L′Amino-3-Fluoro-2-Tridesoxy-2,3,6-L-Galactose (α-Fluoro-2-L-Daunosamine)
- 1 March 1985
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 4 (1), 113-123
- https://doi.org/10.1080/07328308508062953
Abstract
3-Amino-2-fluoro-2,3,6-trideoxy-L-galactose 10 (.alpha.-fluoro-L-daunosamine) was synthesized in 10 steps starting from methyl-2,3-anhydro-4,6-O-benzylidene-.alpha.-D-mannopyranoside (overall yield 70%). Et3N, 3HF complex was used as the fluorinating agent, according to our previous work, for replacement of a mesyl group. Neighboring-group participation leads to a fluorinated product with retention of configuration. The structure of 10 was determined by 1H and 19F NMR spectroscopy.This publication has 14 references indexed in Scilit:
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