Urinary Metabolites of Chlorpropamide in Dogs, Rabbits, and Man.

Abstract

The metabolism of orally administered l-(p-chloro-benzenesulfonyl)-3-n-propylurea, a hypoglycemic agent, was determined by chromatographic examination of urine extracts. The rabbit excreted more than 3/4 of the drug in the urine without chemical alteration. Less than 1/2 of the drug was excreted unchanged by the dog; most of the remainder appeared as p-chlorobenzenesulfonylurea and p-chlorobenzene-sulfonamide. Man excreted unchanged drug and the sulfonamide. One other possible human metabolite as indicated by paper chromatograms was unidentified.