DISTURBED URINARY EXCRETION PATTERN OF OESTROGENS IN NEWBORNS WITH CONGENITAL DISLOCATION OF THE HIP

Abstract

Administration of 0.5–1.0 mg oestradiol benzoate produces hardly any excretion of oestradiol-17β or oestrone in the urine in normal healthy newborns. In newborns with congenital dislocation of the hip, however, it produces an increased excretion of these oestrogens. This provides further support for the assumption that congenital dislocation of the hip is caused by an inborn and probably inherited error of the metabolism of oestrogens.