Use of substituted phenol as phosphate protecting group in the synthesis of deoxyribo-oligonucleotides bearing 5′-phosphomonoester end group

Abstract

A new and efficient approach, which involves the applications of substituted phenols, (i) as 5′-phosphate protecting group and (ii) to increase the binding property of the nucleotidic fragment to benzoylated DEAE-cellulose, has been developed successfully for the synthesis of deoxyribo-oligonucleotides.