Antithyroid Effect of Barbarin (Phenylthiooxazolidone), A Naturally-Occurring Compound from Barbarea.

Abstract

The antithyroid potency of barbarin, a phenylthiooxazolidone obtained from various species of Barbarea and Reseda luteola, was assayed by its inhibition of raioiodine uptake in rat and man. In both species it was found to be approximately 50% as active as goitrin (vinylthiooxazolidone).