Parkinson's--Divergent Causes, Convergent Mechanisms
Top Cited Papers
- 21 May 2004
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 304 (5674), 1120-1122
- https://doi.org/10.1126/science.1098966
Abstract
Parkinson's disease is a progressive neurodegenerative disorder in which there is loss of dopaminergic neurons of the nigrostriatal pathway. Both genetic and environmental causes have been implicated. In their Perspective, [Greenamyre and Hastings][1] discuss the different possible causes of PD in light of new work identifying mutations in the putative mitochondrial protein kinase PINK1 as a cause of familial PD ([ Valente et al .][2]). [1]: http://www.sciencemag.org/cgi/content/full/304/5674/1120 [2]: http://www.sciencemag.org/cgi/content/short/304/5674/1158Keywords
This publication has 20 references indexed in Scilit:
- Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1Science, 2004
- Commentary on “Alpha-synuclein and mitochondria: a tangled skein”Experimental Neurology, 2004
- Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient MiceJournal of Biological Chemistry, 2004
- α-Synuclein Locus Triplication Causes Parkinson's DiseaseScience, 2003
- Molecular Pathways of Neurodegeneration in Parkinson's DiseaseScience, 2003
- Analysis of Steady-state Protein Phosphorylation in Mitochondria Using a Novel Fluorescent Phosphosensor DyeJournal of Biological Chemistry, 2003
- Oxidative stress in Parkinson's diseaseAnnals of Neurology, 2003
- Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein AdductScience, 2001
- Mutation in the α-Synuclein Gene Identified in Families with Parkinson's DiseaseScience, 1997
- Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog SynthesisScience, 1983