Nicotine-11C: Synthesis and distribution kinetics in animals
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in European Journal of Nuclear Medicine and Molecular Imaging
- Vol. 1 (4), 255-258
- https://doi.org/10.1007/bf00252173
Abstract
In order to study “in vivo” the distribution kinetics of (-)-nicotine in animals, this molecule was labeled with carbon-11. Two synthesis methods are described. Immediately after intravenous administration of (-)-nicotine-methyl-11C in rabbits the gamma-camera shows a strong radioactivity build-up in the brain and kidneys. The biological interest of this carbon-11 labeled molecule is discussed.Keywords
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