The Inhibition of Cutaneous Basophil Hypersensitivity Reactions by a Heterologous Anti-Guinea Pig T Cell Serum
- 31 May 1976
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 116 (6), 1646-1651
- https://doi.org/10.4049/jimmunol.116.6.1646
Abstract
Systemic treatment with a heterologous anti-T cell serum of guinea pigs immunized with EA in IFA markedly suppressed CBH reactivity to specific antigen and T cell mitogens, as judged by gross reactivity, histology, and skin histamine. The antiserum produced a marked drop in circulating lymphocytes, mainly at the expense of T cells, as indicated by the ability of surviving lymphocytes to rosette with rabbit RBC. It was postulated that the suppression of CBH reactivity is due to the depletion of T cells, which would have released a factor chemotactic for basophils. The data therefore provide further evidence that cutaneous reactions rich in basophils are primarily dependent on a population of T cells.This publication has 2 references indexed in Scilit: