Attention has been repeatedly called to the association of hypoproteinemia with edema. Recently, Peters and Van Slyke1summarized the existing information. Hypoproteinemia has been observed repeatedly as a result of excessive loss of protein, decreased consumption of nitrogenous foodstuffs, and increased protein wastage. We are presenting a case with low plasma proteins and with edema which does not appear to be due to any one of these three causes. A man, aged 51, Irish born, was admitted to the hospital because of edema of the genitalia and lower extremities. He had been treated for six months at the age of 4 years for "dropsy," which disappeared during that period of observation. For many years there was a slight but constant edema of the feet and ankles. The abdomen had been large since early childhood. Ten years before entry, a brownish discoloration, which was followed by some induration, appeared over