Endothelin stimulates both cAMP formation and phosphatidylinositol hydrolysis in cultured embryonic bovine tracheal cells
Open Access
- 9 March 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 299 (2), 187-191
- https://doi.org/10.1016/0014-5793(92)80244-b
Abstract
Embryonic bovine tracheal (EBTr) cells were found to possess receptors for endothelin (ET) of ET‐1‐selective (ETA)subtype with a K d for ET‐1 of 114 pM and a B max of 12.9 fmol/105 cells. Stimulation of EBTr cells with 100 pM to 100 nM ET‐1 increased the contents of both inositol phosphates and cAMP in a concentration‐dependent manner, indicating that the receptors are coupled to both phosphatidylinositol hydrolysis and cAMP formation in EBTr cells.This publication has 22 references indexed in Scilit:
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