Chemical Modifications That Inhibit Gelation of Sickle Hemoglobin
- 1 April 1974
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (4), 1504-1505
- https://doi.org/10.1073/pnas.71.4.1504
Abstract
Substitution of the N-terminal amino groups with pyridoxal compounds inhibits gelation and increases the solubility of deoxy sickle hemoglobin (Hb S). Pyridoxylation of the alpha chains has considerably more effect than that of the beta chains. The increase in minimum gelling concentration of Hb S that results from modification of the alpha N-termini is the same as that produced by dilution of Hb S with an equal amount of Hb A.Keywords
This publication has 22 references indexed in Scilit:
- Evaluation of sickle hemoglobin and desickling agents by falling ball viscometry.1972
- The Effects of Cyanate In Vitro on Red Blood Cell Metabolism and Function in Sickle Cell AnemiaJCI Insight, 1972
- Relationship between the oxygen affinity and invitro sickling propensity of carbamylated sickle erythrocytesBiochemical and Biophysical Research Communications, 1972
- Ligand-induced conformational dependence of hemoglobin in sickling interactionsJournal of Molecular Biology, 1971
- Potassium Cyanate as an Inhibitor of the Sickling of Erythrocytes In VitroProceedings of the National Academy of Sciences, 1971
- Hemoglobin O Arab in Four Negro Families and Its Interaction with Hemoglobin S and Hemoglobin CNew England Journal of Medicine, 1970
- The effect of β73Asn on the interactions of sickling hemoglobinsBiochimica et Biophysica Acta (BBA) - Protein Structure, 1970
- Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of AllosteryNature, 1970
- Reduction of Methaemoglobin in Haemoglobin Samples using Gel Filtration for Continuous Removal of Reaction ProductsNature, 1967
- STRUCTURE AND PROPERTIES OF HEMOGLOBIN CHARLEM A HUMAN HEMOGLOBIN VARIANT WITH AMINO ACID SUBSTITUTIONS IN 2 RESIDUES OF BETA-POLYPEPTIDE CHAIN1967