Haemoglobin Bart's hydrops foetalis in Thailand*
- 1 May 1967
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 30 (4), 293-308
- https://doi.org/10.1111/j.1469-1809.1967.tb00031.x
Abstract
Summary: Haemoglobin Bart's hydrops foetalis is prevalent in Thailand. A total of fifteen such cases were investigated. The parents were mostly Thais and Chinese. The gestation periods varied between 7 and 10 months. Thirteen were dead in utero and the other two died within 15 min. of delivery. Ten were female and five were male. All were anaemic and oedematous with enlarged and friable placentae, and had massive hepatomegaly. The average values of haematological findings are: haemoglobin concentration, 6.77 g. %; red‐cell count, 2.93 millions/mm.3; packed red‐cell volume, 40.5%; mean corpuscular volume, 140.6 micra3; mean corpuscular haemoglobin, 24.8μμg.; mean corpuscular haemoglobin concentration, 18%. Blood smears showed hypochromia, microcytosis, macrocytosis, target cells, anisocytosis, poikilocytosis, and numerous nucleated red cells. Intraerythrocytic inclusion bodies were found in a few red cells in most cases. Sickling was positive in five out of eight cases. In every case haemoglobin Bart's comprised almost all of the haemoglobin, only trace amounts of haemoglobins A+F being present. A small amount of haemoglobin H was detectable by starch gel in three cases. Average alkali‐resistant haemoglobin was 42.3%.This publication has 21 references indexed in Scilit:
- Case of Intrauterine Death Due to -ThalassaemiaBMJ, 1965
- Hæmoglobin H Disease in Thailand: a Genetical StudyNature, 1964
- Current Concepts of the Genetics of ThalassemiaAnnals of the New York Academy of Sciences, 1964
- HAEMOGLOBINOPATHY ASSOCIATED WITH RECURRENT STILLBIRTHBJOG: An International Journal of Obstetrics and Gynaecology, 1964
- Abnormal Haemoglobins in the Neonatal Period and their Relationship to Thalassaemia*British Journal of Haematology, 1963
- α‐Thalassaemia as a Cause of Hydrops FoetalisBritish Journal of Haematology, 1962
- Abnormal Haemoglobin Production as a Probable Cause of Erythroblastosis and Hydrops Foetalis in Uniovular TwinsActa Haematologica, 1961
- FŒTAL ERYTHROCYTES IN THE MATERNAL CIRCULATIONThe Lancet, 1959
- Genetic and Hæmatological Significance of Hæmoglobin HNature, 1956
- New Hemoglobin in Normal Adult BloodScience, 1955