The large majority of pharmaceutical manufacturers are greatly concerned lest their good name be sullied by entrepreneurs who have entered the field without the traditional background. They are concerned that a sense of responsibility continue to permeate the drug industry. The relations of physicians and manufacturers of pharmaceuticals need review from time to time that we may jointly consider material problems. My purpose is to consider some of the relationships between physicians and the pharmaceutical industry. The methods by which society protects itself in a democratic state in a capitalistic system depend on knowledge, on foresight, on wisdom, and, not least, on a sense of responsibility. These all must be diffused widely throughout the length and breadth of society to provide the guiding force for people in all walks of life. In the past, when science moved slowly and new innovations in therapy were based on inspirational ideas rather than