Accessing Natural Products by Combinatorial Biosynthesis
- 23 March 2004
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science's STKE
- Vol. 2004 (225), pe14
- https://doi.org/10.1126/stke.2252004pe14
Abstract
Enhancement and selective production of the protein phosphatase IIa inhibitor phoslactomycin (PLM) B by rational engineering of the PLM biosynthetic pathway highlights the effectiveness of combinatorial biosynthesis as a promising way to prepare complex natural products and their analogs.Keywords
This publication has 17 references indexed in Scilit:
- Enhancement and Selective Production of Phoslactomycin B, a Protein Phosphatase IIa Inhibitor, through Identification and Engineering of the Corresponding Biosynthetic Gene ClusterJournal of Biological Chemistry, 2003
- Natural Products as Sources of New Drugs over the Period 1981−2002Journal of Natural Products, 2003
- The Biosynthesis of Indolocarbazoles in a Heterologous E. coli HostChemBioChem, 2003
- Characterization of the Biosynthetic Gene Cluster of Rebeccamycin fromLechevalieria aerocolonigenesATCC 39243Bioscience, Biotechnology, and Biochemistry, 2003
- StreptomycesGenetics: A Genomic PerspectiveCritical Reviews in Biotechnology, 2003
- The Biosynthetic Gene Cluster for the Antitumor RebeccamycinChemistry & Biology, 2002
- Cloning of the Staurosporine Biosynthetic Gene Cluster from Streptomyces sp. TP-A0274 and Its Heterologous Expression in Streptomyces lividans.The Journal of Antibiotics, 2002
- Biochemical Engineering of Natural Product Biosynthesis PathwaysMetabolic Engineering, 2001
- The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.Proceedings of the National Academy of Sciences, 1995
- The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frameCurrent Genetics, 1994