Heat-shock responsive elements in the induction of the multidrug resistance gene (MDR1)
- 13 April 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 301 (1), 37-40
- https://doi.org/10.1016/0014-5793(92)80205-u
Abstract
The MDR1 gene, considered to be involved in multidrug resistance of cancer cells, is expressed in liver, kidney, small intestine and the blood-brain barrier. We investigated MDR1 gene expression in the well-differentiated hepatoma cell line HepG2 after exposure to several stresses and found that sodium arsenite treatment increased MDR1 gene expression 2.6-fold. Deletion analysis of the MDR1 promoter indicated that the transcriptional activation after exposure to arsenite depends on a 60-bp region containing two heat-shock responsive elements.Keywords
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