Effects of an ACTH 4-9 related peptide upon intracranial self stimulation and general activity in the rat
- 1 November 1980
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 71 (1), 67-70
- https://doi.org/10.1007/bf00433254
Abstract
Adult male Sprague-Dawley rats were stereotactically implanted with electrodes within the anterior medial forebrain bundle: The rats were trained to respond for intracranial self-stimulation (ICS) and treated with control solution or varying doses of an ACTH 4-9 related synthetic peptide (Org 2766; H-Met(O2)-Glu-His-Phe-d-Lys-Phe-OH). The drug affected ICS as measured in overnight response records, with the highest dose reliably increasing the amount of responding. In a second experiment rats were similarly treated and general activity was assessed. No remarkable changes in activity were present at any tested dose. The findings corroborate previous reports suggesting ACTH-related peptides may be active in a variety of motivated tasks, but less active with respect to general activity.This publication has 14 references indexed in Scilit:
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