Studies on the mechanism of renal transport depression caused by pretreatment with 2,4,5‐trichlorophenoxyacetate
- 31 October 1976
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 2 (2), 323-334
- https://doi.org/10.1080/15287397609529436
Abstract
Relatively low toxicity in the adult has been reported for the organic acid herbicides 2,4‐dichlorophenoxyacetate and 2,4,5‐trichlorophenoxyacetate (2,4,5‐T). Although small doses of these herbicides are excreted rapidly, acute impairment of renal excretion has been reported when large doses of herbicide were administered. After the administration of 2,4,5‐T in vitro analysis of renal proximal tubular function showed a decrease in the activity of the organic acid transport system which handles these herbicides. In addition, the pretreated animals show an impairment in the organic base transport system. To determine the nature of 2,4,5‐T renal depression, renal cortical slices from herbicide‐pretreated animals were studied. Alterations in the initial influx of organic ions, steady‐state accumulation, and efflux were measured. Furthermore, a specific and reversible depression of tissue oxygen consumption was demonstrated. These changes do not appear to be the result of alterations in the gross morphology, electrolyte composition, or cell water content of the renal cortex.This publication has 11 references indexed in Scilit:
- In vitro uptake of organic ions by renal cortical tissue of rats treated acutely with 2,4,5-trichlorophenoxyacetic acidToxicology and Applied Pharmacology, 1976
- In vitro analysis of transport of 2,4,5-trichlorophenoxyacetic acid by rat and dog kidneyFood and Cosmetics Toxicology, 1974
- In vitro uptake of 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) by renal cortical tissue of rabbits and rats*1Toxicology and Applied Pharmacology, 1973
- The fate of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) following oral administration to rats and dogsToxicology and Applied Pharmacology, 1973
- Intracellular distribution and runout of p-aminohippurate in rabbit kidney slicesAmerican Journal of Physiology-Legacy Content, 1970
- The Uptake of Decamethonium and Hexamethonium by Slices of Mouse KidneyActa Pharmacologica et Toxicologica, 1970
- Determination of Intracellular Ionic Concentrations and ActivitiesPublished by Springer Nature ,1969
- UPTAKE OF HEXAMETHONIUM-C14 BY KIDNEY SLICES1965
- STUDIES ON RUN OUT OF P-AMINOHIPPURATE FROM RENAL SLICES1963
- Steps in p-aminohippurate transport by kidney slicesAmerican Journal of Physiology-Legacy Content, 1958