The causes and consequences of genetic heterogeneity in cancer evolution
Top Cited Papers
- 18 September 2013
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 501 (7467), 338-345
- https://doi.org/10.1038/nature12625
Abstract
Recent studies have revealed extensive genetic diversity both between and within tumours. This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge to personalized cancer medicine. A major cause of genetic heterogeneity in cancer is genomic instability. This instability leads to an increased mutation rate and can shape the evolution of the cancer genome through a plethora of mechanisms. By understanding these mechanisms we can gain insight into the common pathways of tumour evolution that could support the development of future therapeutic strategies.Keywords
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