LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
Top Cited Papers
- 15 April 2004
- journal article
- review article
- Published by The Company of Biologists in Development
- Vol. 131 (8), 1663-1677
- https://doi.org/10.1242/dev.01117
Abstract
Wnt signaling through the canonical β-catenin pathway plays essential roles in development and disease. Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in vertebrates, and their Drosophila ortholog Arrow, are single-span transmembrane proteins that are indispensable for Wnt/β-catenin signaling, and are likely to act as Wnt co-receptors. This review highlights recent progress and unresolved issues in understanding the function and regulation of Arrow/Lrp5/Lrp6 in Wnt signaling. We discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular β-catenin degradation apparatus. We also discuss the regulation of Lrp5/Lrp6 by other extracellular ligands, and LRP5 mutations associated with familial osteoporosis and other disorders.Keywords
This publication has 128 references indexed in Scilit:
- A Role of Dishevelled in Relocating Axin to the Plasma Membrane during Wingless SignalingCurrent Biology, 2003
- Kremen2 modulates Dickkopf2 activity during Wnt/lRP6 signalingGene, 2002
- Chromatin-specific regulation of LEF-1–β-catenin transcription activation and inhibition in vitroGenes & Development, 2001
- Wnt Signaling and Heterotrimeric G-Proteins: Strange Bedfellows or a Classic Romance?Biochemical and Biophysical Research Communications, 2001
- Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the MouseDevelopmental Cell, 2001
- Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulationNature, 2000
- An extracellular β-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components 1 1Edited by P. E. WrightJournal of Molecular Biology, 1998
- Molecular Cloning and Characterization of LR3, a Novel LDL Receptor Family Protein with Mitogenic ActivityBiochemical and Biophysical Research Communications, 1998
- Isolation and Characterization ofLRP6,a Novel Member of the Low Density Lipoprotein Receptor Gene FamilyBiochemical and Biophysical Research Communications, 1998
- A frizzled homolog functions in a vertebrate Wnt signaling pathwayCurrent Biology, 1996