Anorganic porous bovine‐derived bone mineral (Bio‐Oss®) and ePTFE membrane in the treatment of peri‐implantitis in cynomolgus monkeys
- 9 September 2003
- journal article
- Published by Wiley in Clinical Oral Implants Research
- Vol. 14 (5), 535-547
- https://doi.org/10.1034/j.1600-0501.2003.00911.x
Abstract
The purpose of the present study was to evaluate the effect of anorganic porous bovine-derived bone mineral (Bio-Oss) and expanded polytetrafluoroethylene (ePTFE) membrane in the treatment of peri-implantitis. A total of 64 implants with a titanium plasma-sprayed (TPS) surface was inserted in eight cynomolgus monkeys (Macaca fascicularis). After a 3-month healing period with plaque control, experimental peri-implantitis characterized by a bone loss of 4-6 mm was induced during a period of 9-18 months. Surgical treatment involving Bio-Oss+membrane, Bio-Oss, membrane, or a conventional flap procedure (control) only was carried out. The animals were sacrificed six months after treatment. Evaluation by clinical parameters, radiography including quantitative digital subtraction radiography, histology, and stereology demonstrated healthy peri-implant tissue irrespective of the applied surgical procedure. However, the amount of re-osseointegration and the total amount of bone (Bio-Oss and regenerated bone) were significantly higher in defects treated with membrane-covered Bio-Oss as compared with the other three treatment procedures. A mean bone-to-implant contact of 36% was obtained within defects treated with membrane-covered Bio-Oss. The corresponding values for the three other treatment procedures were 13-23%. The Bio-Oss particles were in general highly integrated within the regenerated bone, but the particles in the occlusal part of the defects were entirely surrounded by connective tissue irrespective of membrane coverage. The present study demonstrates that surgical treatment involving Bio-Oss covered by an ePTFE membrane is a useful treatment modality of experimental peri-implantitis around implants with a TPS surface in cynomolgus monkeys. However, the treatment outcome is not as encouraging as seen with membrane-covered autogenous bone graft particles documented in a study with same experimental design.Keywords
This publication has 45 references indexed in Scilit:
- Absorbable versus nonabsorbable membranes and bone grafts in the treatment of ligature‐induced peri‐implantitis defects in dogsClinical Oral Implants Research, 2001
- Sinus floor augmentation with simultaneous placement of dental implants using a combination of deproteinized bone xenografts and recombinant human osteogenic protein‐l. A histometric study in miniature pigs.Clinical Oral Implants Research, 1999
- Treatment of ligature-induced peri-implantitis defects by regenerative procedures. A clinical study in dogs.Journal of Oral Science, 1999
- Evaluation of a new bioresorbable barrier to facilitate guided bone regeneration around exposed implant threadsInternational Journal of Oral & Maxillofacial Surgery, 1998
- Ligature‐induced marginal inflammation around osseointegrated implants and ankylosed teeth. Clinical and radiographic observations in cynomolgus monkeys (Macaca fascicularis).Clinical Oral Implants Research, 1993
- Treatment of an early implant failure according to the principles of guided tissue regeneration (GTR)Clinical Oral Implants Research, 1992
- STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENTThe Lancet, 1986
- The microbiology of ligature‐induced periodontitis in the cynomolgus monkeyJournal of Periodontal Research, 1981
- Establishing and maintaining clinically healthy gingivae in Rhesus monkeysJournal of Clinical Periodontology, 1979
- Primate Model for Testing Periodontal Treatment Procedures: I. Histologic Investigation of Localized Periodontal Pockets Produced by Orthodontic ElasticsThe Journal of Periodontology, 1975