Ascorbic Acid and Chronic Schizophrenia

Abstract

Milner (1963), using urinary saturation tests to determine ascorbic acid levels in a group of male chronic schizophrenics, reported that far higher doses of ascorbic acid were required to achieve saturation in that group than in normal subjects. Briggs (1962) observed hypovitaminosis C in schizophrenics, and postulated a disturbance of ascorbic acid metabolism which could be relevant to the biochemical basis of schizophrenia.