A Mechanism of Chlorothiazide-Enhanced Effectiveness of Antihypertensive Ganglioplegic Drugs
- 1 March 1959
- journal article
- research article
- Published by Wolters Kluwer Health in Cell Metabolism
- Vol. 19 (3), 360-365
- https://doi.org/10.1161/01.cir.19.3.360
Abstract
Chlorothiazide decreases plasma volume, heart size, and cardiac output. The oligemia stimulates vasomotor tone; this tends to maintain arterial pressure because chronic arterial hypertension is characteristically self-sustaining and homeostatic. This oligemic stimulation of vasomotor tone results in increased sensitivity to the antihypertensive effect of drugs depressing or blocking vasomotor function.Keywords
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