Experimental Trichuriasis. II. Anthelmintic Screening against Trichuris muris in the Albino Mouse

Abstract

The use of Trichuris muris in the mouse for drug screening is described. Compounds were administered by gavage in aqueous solution or suspension approximately 40 days after infection and estimates of activity were based on recoveries of worms at autopsy. Bephenium hydroxynaphthoate, n-butyl chloride, diethylcarbamazine citrate, 1,8-dihydroxyanthraquinone, dithiazanine iodide, hexachloro-ethane, hexylresorcinol, oil of chenopodium, phthalofyne, piperazine phosphate, piperazine stearate, santonin and tetrachloroethylene did not have any significant activity. The proteolytic enzymes ficin and papaine were highly active. The validity of the screen cannot be considered proven.