The Resolution and Absolute Stereochemistry of the Enantiomers ofcis-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine (BCH189): Equipotent Anti-HIV Agents
- 1 February 1993
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 12 (2), 225-236
- https://doi.org/10.1080/07328319308021208
Abstract
Enzymic resolution of the monophosphate derivative of (/pm)-cis-1[2-(hydroxymethyl)-1, 3-oxathiolan-5-yl]cytosine using the 5′-nucleotidase from Crotalus atrox venom has allowed facile access to the individual enantimers. The absolute stereochemistry of the preferred (-)-enantiomer (8b) has been determined by X-ray crystallography of the bromine-contining derivative (10).Keywords
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