Ketorolac-associated renal morbidity: risk factors in cardiac surgical infants

Abstract

We aimed to identify the risk factors for acute kidney injury in infants who have received ketorolac after a cardiac surgical procedure by identifying patients with a ≥50% increase in serum creatinine from baseline and matching them by age with three controls that had <50% increase in serum creatinine. Significant differences in primary surgical procedure, baseline serum creatinine, and concomitant aspirin use were noted. We conclude that the concomitant use of aspirin with ketorolac is associated with increased renal morbidity in young post-cardiac surgical infants.