Potentiation of pancuronium induced neuromuscular blockade by calcium channel blockersin vitro
- 1 September 1985
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 64 (3-4), 285-293
- https://doi.org/10.1007/bf01256473
Abstract
The calcium channel blockers verapamil, methoxyverapamil, diltiazem, and nisoldipine have been tested for interactions with the nondepolarizing muscle relaxant pancuronium bromide by using the indirectly stimulatedin vitro preparation of the rat hemidiaphragm. Dose response curves of each calcium channel blocker, pancuronium bromide, and combinations of both were determined. Each of the four calcium channel blocking drugs showed agonistic interaction in potentiating pancuronium induced neuromuscular blockade.This publication has 21 references indexed in Scilit:
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